Data/hora: 19/05/2024 10:34:35

Provedor de dados: 	5	
País: 	France	
Título: 	Energy and Antioxidant Responses of Pacific Oyster Exposed to Trace Levels of Pesticides	
Autores: 	Epelboin, Yanouk; Quere, Claudie; Pernet, Fabrice; Pichereau, Vianney; Corporeau, Charlotte.	
Data: 	2015-09	
Ano: 	2015	
Resumo: 	Here, we assess the physiological effects induced by environmental concentrations of pesticides in Pacific oyster Crassostrea gigas. Oysters were exposed for 14 d to trace levels of metconazole (0.2 and 2 mu g/L), isoproturon (0.1 and 1 mu g/L), or both in a mixture (0.2 and 0.1 mu g/L, respectively). Exposure to trace levels of pesticides had no effect on the filtration rate, growth, and energy reserves of oysters. However, oysters exposed to metconazole and isoproturon showed an overactivation of the sensing-kinase AMP-activated protein kinase alpha (AMPK alpha), a key enzyme involved in energy metabolism and more particularly glycolysis. In the meantime, these exposed oysters showed a decrease in hexokinase and pyruvate kinase activities, whereas 2-DE proteomic revealed that fructose-1,6-bisphosphatase (F-1,6-BP), a key enzyme of gluconeogenesis, was upregulated. Activities of antioxidant enzymes were higher in oysters exposed to the highest pesticide concentrations. Both pesticides enhanced the superoxide dismutase activity of oysters. Isoproturon enhanced catalase activity, and metconazole enhanced peroxiredoxin activity. Overall, our results show that environmental concentrations of metconazole or isoproturon induced subtle changes in the energy and antioxidant metabolisms of oysters.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00284/39490/44227.pdf

DOI:10.1021/acs.chemrestox.5b00269

https://archimer.ifremer.fr/doc/00284/39490/	
Editor: 	Amer Chemical Soc	
Formato: 	application/pdf	
Fonte: 	Chemical Research In Toxicology (0893-228X) (Amer Chemical Soc), 2015-09 , Vol. 28 , N. 9 , P. 1831-1841	
Fonte: 	2015 American Chemical Society

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